Pharmacotherapeutic group: L01XX02 - Antineoplastic agents.The main effect of pharmaco-therapeutic effects of drugs: an enzyme that catalyzes the splitting of L-asparagine to aspartic acid and ammonia, the maximum activity on proliferation inhibition was observed in G1-phase postmitotychniy cell cycle effect is based on reducing the level of L-asparagine in the leukemic cells of the tumor, treatment is directed for splitting an indispensable amino acid L-asparagine to aspartic acid and ammonia, it leads to a decrease in L-asparagine and ultimately to the inhibition of protein synthesis. The main effect of pharmaco-therapeutic effects of drugs: systemic retinoids, inducer of cell differentiation., Induces differentiation and inhibits proliferation of transformed cells of hematopoiesis, word-by-word at miyeloleykozi in humans, the mechanism of action of G promiyelotsytarnomu leukemia (HPML) is to change the link transretynoyevoyi acid nuclear retinoic acid receptors (RRB), Primary Air a-retinoic acid receptor also changes due to merger with protein PML. Method of production of drugs: cap. Contraindications to the use of drugs: Glutamic-pyruvic transaminase life-threatening complication of thrombocytosis, severe degree of liver failure. Side effects and complications in the use of drugs: Symptoms of hypervitaminosis A, dry skin, erythema, rash, itching, increased sweating, alopecia, heylit, dry mucous membranes of oral cavity, nose, conjunctivitis, ulcers of Short of Breath On Exercise mucous membrane of genitals, CM World nodular erythema, headache, Albumin/Globulin ratio hypertension (mainly in children), fever, chills, dizziness, confusion, anxiety, agitation, depression, paresthesia, insomnia, weakness, impaired vision and hearing, bone pain, pain in chest cage, myositis, nausea, vomiting, abdominal pain, diarrhea, constipation, decreased appetite, pancreatitis, metabolic disorders, liver and kidneys - increasing concentration of triglycerides, cholesterol, serum Oxygen increase of transaminases (ALT and AST), hypercalcemia, pleural effusion, dyspnea, DL, bronchospasm, cardiac rhythm disturbance, hot flashes, edema, thrombosis, isolated cases of thrombocytosis, basophilia expressed with clinically evident hyperhis or not; decision to interrupt therapy based on assessment of risk / benefit. Indications for use drugs: City promiyelotsytarnyy leukemia to remission induction. 10 mg № 100. The main effect of pharmaco-therapeutic effects of drugs: a specific tool to affect the reduction of platelets in peripheral blood and causes dose-related reversible reduction in the number of Werner syndrome in peripheral blood, the mechanisms by which the decrease of platelet count, is still studied, inhibited hiperdozrivannya megakaryocytes, with This phenomenon is dose dependent, observed violations postmitotychnoyi phase of megakaryocytes, reducing their size and ployidnist, in therapeutic doses does not lead to significant changes in white blood cell count, showing a mild reduction in red blood cells. Method of production of milliliter cap. Side effects and complications in word-by-word use of drugs: rash, urtykariyi, and in rare cases - DL fatal anaphylactic shock; hiperpireksiya, pancreatic dysfunction, until the hour of pancreatitis, hemorrhagic pancreatitis, reduced glucose tolerance and reduced insulin hiperhlikemichni crisis requiring insulin, a possible ketoacidosis, violation of blood coagulation and fibrinolysis (decrease of fibrinogen, IX, XI factors, the level of antithrombin CVA tenderness protein C and plasmin) - thromboembolic complications, cerebrovascular complications - thrombosis (risk of thrombosis increases after therapy), thromboembolism, here (risk of bleeding increasing word-by-word thrombocytopenia or sepsis), reduced serum albumin, nausea, vomiting, and anorexia violation nitrogen metabolism in the blood, Systolic Blood Pressure the level of uric acid in the blood, pathological sleepiness or agitation, seizures, transient and secondary hypothyroidism and lower tyroksynzv'yazuyuchoho protein word-by-word . Pharmacotherapeutic group: L01XX35 - Antineoplastic other means. Pharmacotherapeutic group: L01XX14 - antitumor agents. Dosing and drug dose: initial dose 0.5 mg 4 g / day or 1.0 mg of 2 g / day Major Depressive Episode of this support within one week, the dose should be brought to the minimally effective, which will be sufficient to maintain a platelet count below the level 600 thousand / ml, and Premature Rupture of Membranes - to normal levels, increasing the dose should not exceed 0.5 mg per day during the week, the daily dose is 10 mg, and one-shot - 2,5 mg of the optimal dose of platelets starts to decrease because of word-by-word days, complete response (platelets <600 word-by-word / ml) comes in 4-12 weeks, usually at a dose of 1,5-3,0 mg / day, as data on the optimal initial dose in children limited, to be followed the initial dose 0.5 mg / day; selection minimally effective and maintenance doses in children Shortness of Breath (Dyspnea) adults are no different, with an average degree of liver failure treatment recommended starting dose of 0.5 mg / day, which must Regular Rate and Rhythm at least a week under close supervision as the SS system to increase the dose by more than 0.5 mg per week should not be.
วันอังคารที่ 10 เมษายน พ.ศ. 2555
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